Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

This review focuses on the neuronal and circuit mechanisms involved in the generation of
the theta (θ) rhythm and of its participation in behavior. Data have accumulated indicating …

The development of technologies to protect or enhance memory in older people is an
enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial …

Understanding normal brain aging and developing methods to maintain or improve
cognition in older adults are major goals of fundamental and translational neuroscience …

Working memory is thought to result from sustained neuron spiking. However, computational
models suggest complex dynamics with discrete oscillatory bursts. We analyzed local field …

Persistent spiking has been thought to underlie working memory (WM). However, virtually all
of the evidence for this comes from studies that averaged spiking across time and across …

Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

Theories on the functions of the hippocampal system are based largely on two fundamental
discoveries: the amnestic consequences of removing the hippocampus and associated …

Theta and gamma frequency oscillations occur in the same brain regions and interact with
each other, a process called cross-frequency coupling. Here, we review evidence for the …

Despite the several-thousand-fold increase of brain volume during the course of mammalian
evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for …