The past decade has seen substantial research on exact inference for contingency tables,
both in terms of developing new analyses and developing efficient algorithms for …

In 1982, I published several issues of a samdizat scholarly journal called Random ization
with the aid of an 8-bit, I-MH personal computer with 48K of memory (upgraded to 64K later …

Response-adaptive designs in clinical trials are schemes for patient assignment to
treatment, the goal of which is to place more patients on the better treatment based on …

A functional limit theorem is proved for multitype continuous time Markov branching
processes. As consequences, we obtain limit theorems for the branching process stopped …

Most medical trials are monitored for early evidence of treatment differences or harmful side-
effects and many sequential methods have been proposed for this. Similarly, data collected …

Conventional randomized clinical trials provide a powerful and scientifically rigorous method
for comparing medical therapies, but designs using 50-50 randomization (or any other …

Adaptive design has become an important tool in modern pharmaceutical research and
development. Compared to a classic trial design with static features, an adaptive design …

We consider central limit theory for urn models in which balls are not necessarily replaced
after being drawn, giving rise to negative diagonal entries in the generating matrix. Under …

Adaptive clinical trials have attracted the attention of statisticians because they allow for
information accrued early in the trial to influence the allocation of treatment of later enrolled …

The randomized play-the-winner rule is an adaptive randomized design, based on an urn
model, that is used occasionally in clinical trials. This paper discusses practical and …