Sepsis biomarkers and diagnostic tools with a focus on machine learning

M Komorowski, A Green, KC Tatham, C Seymour… - …, 2022 - thelancet.com
Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

[HTML][HTML] New approaches to understanding the immune response to vaccination and infection

D Furman, MM Davis - Vaccine, 2015 - Elsevier
The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …

Metabolomic analyses reveal new stage-specific features of COVID-19

H Jia, C Liu, D Li, Q Huang, D Liu… - European …, 2022 - Eur Respiratory Soc
The current pandemic of coronavirus disease 2019 (COVID-19) has affected> 160 million
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …

Comprehensive metabolic profiling of inflammation indicated key roles of glycerophospholipid and arginine metabolism in coronary artery disease

Q Zhu, Y Wu, J Mai, G Guo, J Meng, X Fang… - Frontiers in …, 2022 - frontiersin.org
Background Systemic immune inflammation is a key mediator in the progression of coronary
artery disease (CAD), concerning various metabolic and lipid changes. In this study, the …

Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

S Chettimada, DR Lorenz, V Misra, ST Dillon… - Scientific reports, 2018 - nature.com
Exosomes are nanovesicles released from most cell types including immune cells. Prior
studies suggest exosomes play a role in HIV pathogenesis, but little is known about …

Prediction of sepsis mortality using metabolite biomarkers in the blood: a meta-analysis of death-related pathways and prospective validation

J Wang, Y Sun, S Teng, K Li - BMC medicine, 2020 - Springer
Background Sepsis is a leading cause of death in intensive care units (ICUs), but outcomes
of individual patients are difficult to predict. The recently developed clinical metabolomics …

Diagnosis of Bovine Respiratory Disease in feedlot cattle using blood 1H NMR metabolomics

C Blakebrough-Hall, A Dona, MJ D'occhio… - Scientific reports, 2020 - nature.com
Current diagnosis methods for Bovine Respiratory Disease (BRD) in feedlots have a low
diagnostic accuracy. The current study aimed to search for blood biomarkers of BRD using …

Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study

JK Frediani, DP Jones, N Tukvadze, K Uppal… - PloS one, 2014 - journals.plos.org
We aimed to characterize metabolites during tuberculosis (TB) disease and identify new
pathophysiologic pathways involved in infection as well as biomarkers of TB onset …

Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients

S Chettimada, DR Lorenz, V Misra, SM Wolinsky… - BMC immunology, 2020 - Springer
Abstract Background Extracellular vesicles (EVs) are nano-sized particles secreted by most
cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases …

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

AS Herrera-Van Oostdam, JE Castañeda-Delgado… - PLoS …, 2021 - journals.plos.org
Viral sepsis has been proposed as an accurate term to describe all multisystemic
dysregulations and clinical findings in severe and critically ill COVID-19 patients. The …