Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …

The unique structure and composition of articular cartilage is critical for its physiological
function. However, this architecture may get disrupted by degeneration or trauma. Due to the …

Mechanical stimuli regulate the chondrogenic differentiation of mesenchymal stem cells and
the homeostasis of chondrocytes, thus affecting implant success in cartilage tissue …

Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue
with distinct structural and functional properties. Although several approaches to cartilage …

Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor composed of an
alpha and a beta subunit. HIF-1α is a master regulator of cellular response to hypoxia by …

Articular cartilage is characterized by a low density of chondrocytes surrounded by an
abundant extracellular matrix (ECM) consisting of a dense mixture of collagens …

The primary aim of this article is to provide a biological rhythm model based on previous
theoretical and experimental findings to promote more comprehensive studies of rhythmic …

Cartilage tissue, encompassing hyaline cartilage, fibrocartilage, and elastic cartilage, plays
a pivotal role in the human body because of its unique composition, structure, and …

The circadian clock, a collection of endogenous cellular oscillators with an approximate 24‐
h cycle, involves autoregulatory transcriptional/translational feedback loops to enable …

This paper presents an innovative experimental setup that employs the principles of audio
technology to subject adherent cells to rhythmic vertical vibrations. We employ a novel …