Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease
R Lathe, D St. Clair - Biological Reviews, 2023 - Wiley Online Library
The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …
[HTML][HTML] Crossing borders in Alzheimer's disease: AT cell's perspective
L Van Olst, L Coenen, JM Nieuwland… - Advanced drug delivery …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting millions of people
worldwide. While different immunotherapies are imminent, currently only disease-modifying …
worldwide. While different immunotherapies are imminent, currently only disease-modifying …
A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders
Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …
Human herpesvirus 6 detection in Alzheimer's disease cases and controls across multiple cohorts
MA Allnutt, K Johnson, DA Bennett, SM Connor… - Neuron, 2020 - cell.com
The interplay between viral infection and Alzheimer's disease (AD) has long been an area of
interest, but proving causality has been elusive. Several recent studies have renewed the …
interest, but proving causality has been elusive. Several recent studies have renewed the …
Common variants contribute to intrinsic human brain functional networks
The human brain forms functional networks of correlated activity, which have been linked
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease
Neuroinflammation has been increasingly recognized to play a critical role in Alzheimer's
disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid …
disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid …
Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases
Highlights•T cells play a role in neurodegenerative diseases.•T cells recognize α-synuclein
derived peptides in Parkinson's patients.•T cell recognition and susceptibility to Parkinson's …
derived peptides in Parkinson's patients.•T cell recognition and susceptibility to Parkinson's …
A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study
Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses
a worldwide public health challenge. A neuroimaging biomarker would significantly improve …
a worldwide public health challenge. A neuroimaging biomarker would significantly improve …
Biomarkers: our path towards a cure for Alzheimer disease
R Tarawneh - Biomarker insights, 2020 - journals.sagepub.com
Over the last decade, biomarkers have significantly improved our understanding of the
pathophysiology of Alzheimer disease (AD) and provided valuable tools to examine different …
pathophysiology of Alzheimer disease (AD) and provided valuable tools to examine different …
Exploiting discriminative regions of brain slices based on 2D CNNs for Alzheimer's disease classification
F Ren, C Yang, Q Qiu, N Zeng, C Cai, C Hou… - Ieee …, 2019 - ieeexplore.ieee.org
Convolutional neural networks (CNNs)-based classifiers improve the accuracy of diagnosis
and prediction for Alzheimer's disease (AD). However, exploiting specific brain regions with …
and prediction for Alzheimer's disease (AD). However, exploiting specific brain regions with …