Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease

R Lathe, D St. Clair - Biological Reviews, 2023 - Wiley Online Library
The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

[HTML][HTML] Crossing borders in Alzheimer's disease: AT cell's perspective

L Van Olst, L Coenen, JM Nieuwland… - Advanced drug delivery …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting millions of people
worldwide. While different immunotherapies are imminent, currently only disease-modifying …

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders

EO Adewuyi, EK O'Brien, DR Nyholt, T Porter… - Communications …, 2022 - nature.com
Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …

Human herpesvirus 6 detection in Alzheimer's disease cases and controls across multiple cohorts

MA Allnutt, K Johnson, DA Bennett, SM Connor… - Neuron, 2020 - cell.com
The interplay between viral infection and Alzheimer's disease (AD) has long been an area of
interest, but proving causality has been elusive. Several recent studies have renewed the …

Common variants contribute to intrinsic human brain functional networks

B Zhao, T Li, SM Smith, D Xiong, X Wang, Y Yang… - Nature Genetics, 2022 - nature.com
The human brain forms functional networks of correlated activity, which have been linked
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease

A Ghosh, MM Comerota, D Wan, F Chen… - Science translational …, 2020 - science.org
Neuroinflammation has been increasingly recognized to play a critical role in Alzheimer's
disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid …

Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases

CSL Arlehamn, F Garretti, D Sulzer, A Sette - Current opinion in …, 2019 - Elsevier
Highlights•T cells play a role in neurodegenerative diseases.•T cells recognize α-synuclein
derived peptides in Parkinson's patients.•T cell recognition and susceptibility to Parkinson's …

A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study

K Zhao, P Chen, A Alexander-Bloch, Y Wei… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses
a worldwide public health challenge. A neuroimaging biomarker would significantly improve …

Biomarkers: our path towards a cure for Alzheimer disease

R Tarawneh - Biomarker insights, 2020 - journals.sagepub.com
Over the last decade, biomarkers have significantly improved our understanding of the
pathophysiology of Alzheimer disease (AD) and provided valuable tools to examine different …

Exploiting discriminative regions of brain slices based on 2D CNNs for Alzheimer's disease classification

F Ren, C Yang, Q Qiu, N Zeng, C Cai, C Hou… - Ieee …, 2019 - ieeexplore.ieee.org
Convolutional neural networks (CNNs)-based classifiers improve the accuracy of diagnosis
and prediction for Alzheimer's disease (AD). However, exploiting specific brain regions with …