A myriad of naturally occurring and synthetic structures are capable of transferring the
energy of light. Few, however, allow for this energy transfer to enable a type II photochemical …

Photosensitizers in photodynamic therapy allow for the transfer and translation of light
energy into a type II chemical reaction. In clinical practice, photosensitizers arise from three …

Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Purpose To report the neurocognitive findings in a phase III randomized trial evaluating
survival and neurologic and neurocognitive function in patients with brain metastases from …

Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000
Americans annually. The prognosis for these patients is poor, with median survival times …

Brain metastases occur in 20–40% of patients with cancer and their frequency has
increased over time. Lung, breast and skin (melanoma) are the commonest sources of brain …

Purpose: This phase III randomized trial evaluated survival as well as neurologic and
neurocognitive function in patients with brain metastases from solid tumors receiving whole …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Brain metastases are an important sequelae of many types of cancer, most commonly lung
cancer. Current treatment options include whole-brain radiation therapy (WBRT), surgical …

The brain requires a stable internal environment, which is established by the integrity of the
blood-brain barrier (BBB). The efficacy of chemotherapeutics in the treatment of brain …