Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Practice guideline update recommendations summary: disorders of consciousness: report of the Guideline Development, Dissemination, and Implementation …

JT Giacino, DI Katz, ND Schiff, J Whyte, EJ Ashman… - Neurology, 2018 - AAN Enterprises
Objective To update the 1995 American Academy of Neurology (AAN) practice parameter on
persistent vegetative state and the 2002 case definition on minimally conscious state (MCS) …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

Disorders of consciousness after acquired brain injury: the state of the science

JT Giacino, JJ Fins, S Laureys, ND Schiff - Nature Reviews Neurology, 2014 - nature.com
The concept of consciousness continues to defy definition and elude the grasp of
philosophical and scientific efforts to formulate a testable construct that maps to human …

The repetition of behavioral assessments in diagnosis of disorders of consciousness

S Wannez, L Heine, M Thonnard… - Annals of …, 2017 - Wiley Online Library
Objective To determine whether repeated examinations using the Coma Recovery Scale‐
Revised (CRS‐R) have an impact on diagnostic accuracy of patients with disorders of …

Preservation of brain activity in unresponsive patients identifies MCS star

A Thibaut, R Panda, J Annen, LRD Sanz… - Annals of …, 2021 - Wiley Online Library
Objective Brain‐injured patients who are unresponsive at the bedside (ie, vegetative
state/unresponsive wakefulness syndrome–VS/UWS) may present brain activity similar to …

Accuracy of EEG biomarkers in the detection of clinical outcome in disorders of consciousness after severe acquired brain injury: preliminary results of a pilot study …

F Di Gregorio, F La Porta, V Petrone, S Battaglia… - Biomedicines, 2022 - mdpi.com
Accurate outcome detection in neuro-rehabilitative settings is crucial for appropriate long-
term rehabilitative decisions in patients with disorders of consciousness (DoC). EEG …

Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study

J Stender, O Gosseries, MA Bruno, V Charland-Verville… - The Lancet, 2014 - thelancet.com
Background Bedside clinical examinations can have high rates of misdiagnosis of
unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The …

Comprehensive systematic review update summary: disorders of consciousness: report of the guideline development, dissemination, and implementation …

JT Giacino, DI Katz, ND Schiff, J Whyte, EJ Ashman… - Neurology, 2018 - AAN Enterprises
Objective To update the 1995 American Academy of Neurology (AAN) practice parameter on
persistent vegetative state and the 2002 case definition for the minimally conscious state …

From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of …

MA Bruno, A Vanhaudenhuyse, A Thibaut… - Journal of …, 2011 - Springer
Functional neuroimaging and electrophysiology studies are changing our understanding of
patients with coma and related states. Some severely brain damaged patients may show …