Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …

Several cellular signaling pathways are regulated by ADP-ribosylation, a posttranslational
modification catalyzed by members of the ARTD superfamily. Tankyrases are …

Tankyrase 1 and tankyrase 2 are poly (ADP‐ribosyl) ases that are distinguishable from other
members of the enzyme family by the structural features of the catalytic domain, and the …

The Wnt/β‐catenin signalling pathway is pivotal for stem cell function and the control of
cellular differentiation, both during embryonic development and tissue homeostasis in …

Flavones are known as an inhibitor of tankyrase, a potential drug target of cancer. We here
expedited the use of different computational approaches and presented a fast, easy, cost …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Canonical WNT signaling is an important developmental pathway that has attracted
increased attention for anticancer drug discovery. From the production and secretion of WNT …

Background New pharmacologic targets are urgently needed to treat or prevent lung cancer,
the most common cause of cancer death for men and women. This study identified one such …

The widespread proliferation of artificial intelligence (AI) and machine learning (ML)
methods has a profound effect on the drug discovery process. However, many scientists are …

Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …