[HTML][HTML] Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides

N Malanovic, K Lohner - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
A number of cationic antimicrobial peptides, effectors of innate immunity, are supposed to
act at the cytoplasmic membrane leading to permeabilization and eventually membrane …

Antimicrobial peptides targeting gram-positive bacteria

N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

A de Breij, M Riool, RA Cordfunke… - Science translational …, 2018 - science.org
Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …

[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator

D Xhindoli, S Pacor, M Benincasa, M Scocchi… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

[HTML][HTML] Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

S Riedl, D Zweytick, K Lohner - Chemistry and physics of lipids, 2011 - Elsevier
Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Multifunctional host defense peptides: intracellular‐targeting antimicrobial peptides

P Nicolas - The FEBS journal, 2009 - Wiley Online Library
There is widespread acceptance that cationic antimicrobial peptides, apart from their
membrane‐permeabilizing/disrupting properties, also operate through interactions with …

[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

G Wang, B Mishra, RF Epand, RM Epand - Biochimica et Biophysica Acta …, 2014 - Elsevier
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …

The revitalization of antimicrobial peptides in the resistance era

Y Liu, J Shi, Z Tong, Y Jia, B Yang, Z Wang - Pharmacological Research, 2021 - Elsevier
The antibiotic resistance crisis is becoming incredibly thorny due to the indiscriminate
employment of antibiotics in agriculture and aquaculture, such as growth promoters, and the …

Antimicrobial peptides increase line tension in raft-forming lipid membranes

VR Koynarev, KKA Borgos, J Kohlbrecher… - Journal of the …, 2024 - ACS Publications
The formation of phase separated membrane domains is believed to be essential for the
function of the cell. The precise composition and physical properties of lipid bilayer domains …