The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of
citric acid cycle anaplerosis. In this manuscript we present results that collectively …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption
is upregulated relative to healthy cells. This metabolic reprogramming often depends upon …

Cancer cells require a robust supply of reduced nitrogen to produce nucleotides, non-
essential amino acids and a high cellular redox activity. Glutamine provides a major …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …

Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism,
contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA …

[Frontiers in Bioscience 12, 332-343, January 1, 2007] 332 Glutamine in the central nervous
system: function and dysfunction Jan Page 1 [Frontiers in Bioscience 12, 332-343, January 1 …

Glutamine is a multifaceted amino acid that plays key roles in many metabolic pathways and
also fulfils essential signaling functions. Although classified as non-essential, recent …