Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
DAMPs and NETs in sepsis
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …
infection. Much has been focused on host response to pathogens mediated through the …
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
Akt signaling pathway in macrophage activation and M1/M2 polarization
E Vergadi, E Ieronymaki, K Lyroni… - The Journal of …, 2017 - journals.aai.org
Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …
signals, macrophages obtain an array of activation phenotypes, described by the broad …
The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review
X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …
response to infection. Recently was been found that pyroptosis is a unique form of …
Immunotherapeutic implications of IL-6 blockade for cytokine storm
T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Taylor & Francis
IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
[HTML][HTML] Inflammasome activation triggers blood clotting and host death through pyroptosis
Inflammasome activation and subsequent pyroptosis are critical defense mechanisms
against microbes. However, overactivation of inflammasome leads to death of the host …
against microbes. However, overactivation of inflammasome leads to death of the host …
Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions
RA Aglietti, EC Dueber - Trends in immunology, 2017 - cell.com
Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
Mechanism of membrane pore formation by human gasdermin‐D
E Mulvihill, L Sborgi, SA Mari, M Pfreundschuh… - The EMBO …, 2018 - embopress.org
Abstract Gasdermin‐D (GSDMD), a member of the gasdermin protein family, mediates
pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts …
pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts …
[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome
JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …