Noninvasive disease monitoring and risk stratification by circulating tumor DNA (ctDNA)
profiling has become a potential novel strategy for patient management in B-cell lymphoma …

Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …

The assessment of the cancer mutational profile is crucial for patient management,
stratification, and therapeutic decisions. At present, in hematological malignancies with a …

The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-
cell lymphoma 2 (BCL2), via the t (14; 18) translocation, to a proliferating clone, poised to …

Follicular lymphoma (FL) is an indolent malignancy of mature B cells that are arrested at the
germinal center (GC) stage. 1, 2 In physiological GC reactions, B cells undergo clonal …

Although TP53 is commonly mutated in transformed follicular lymphoma, mutations are
reported in< 5% of pretreatment follicular lymphoma (FL) specimens. We assayed archival …

The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation
(SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions …

We investigated clinical and genetic characteristics of high-risk follicular lymphoma (FL), that
lacked evidence of large cell transformation at diagnosis, in the rituximab era. First, we …

Primary cutaneous follicle center lymphoma (PCFCL) is a rare mature B-cell lymphoma with
an unknown etiology. PCFCL resembles follicular lymphoma (FL) by cytomorphologic and …

Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for
understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin …