In the context of the structural complexity necessary for a molecule to selectively display a
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …

Objective Oxidative stress plays a pivotal role in neurodegenerative diseases. Astaxanthin
(AST) can play a neuroprotective role owing to its long-chain conjugated unsaturated double …

Alzheimer's disease (AD) is an age-related neurological disorder. Currently, there is no
effective cure for AD due to its complexity in pathogenesis. In light of the complex …

Background and Purpose The development of effective therapeutic strategies against
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …

Recent findings unveil the pharmacological modulation of imidazoline I 2 receptors (I 2-IR)
as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we …

Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that
suffer from neurodegenerative disorders, are orphans from a structural point of view, and …

Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in
animal models of neurodegeneration, such as Alzheimer's disease (AD). We recently …

Brain aging and dementia are current problems that must be solved. The levels of
imidazoline 2 receptors (I 2-IRs) are increased in the brain in Alzheimer's disease (AD) and …

Abstracts Agmatine is a biogenic amine synthesized following decarboxylation of L-arginine
by the enzyme arginine decarboxylase and exhibits favourable outcome in …

In searching for novel targets to design antidepressants, among the characterized
imidazoline receptors (IR), I2 receptors are an innovative therapeutical approach since they …