RNA-binding proteins play a central role in cellular metabolism by orchestrating the complex
interactions of coding, structural and regulatory RNA species. The SAFB (scaffold …

The nucleus is a complex organelle that hosts the genome and is essential for vital
processes like DNA replication, DNA repair, transcription, and splicing. The genome is non …

Many microRNAs (miRNAs) are generated from primary transcripts containing multiple
clustered stem-loop structures that are thought to be recognized and cleaved by the …

Abstract FUS (Fused-in-Sarcoma) is a multifunctional DNA/RNA binding protein linked to
familial amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). Since FUS is …

The nucleus limited long-noncoding hsrω-n transcripts, hnRNPs, and some other RNA
processing proteins organize nucleoplasmic omega speckles in Drosophila. Unlike other …

Scaffold attachment factor B1 (SAFB 1) is an integral component of the nuclear matrix of
vertebrate cells. It binds to DNA on scaffold/matrix attachment region elements, as well as to …

Long noncoding RNAs (lncRNAs) have a crucial role in epigenetic, transcriptional and
posttranscriptional regulation of gene expression. Many of these regulatory lncRNAs, such …

Satellite repeats make up a large fraction of the genomes of many higher eukaryotes. Until
recently these sequences were viewed as molecular parasites with few functions …

Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of
distribution and genomic context of S/MARs is thought to be important for processes such as …

Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-
associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly …