The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia

O Delbono, ACZ Rodrigues, HJ Bonilla… - Ageing research reviews, 2021 - Elsevier
Examining neural etiologic factors' role in the decline of neuromuscular function with aging
is essential to our understanding of the mechanisms underlying sarcopenia, the age …

Sarcopenia: what is the origin of this aging-induced disorder?

T Gustafsson, B Ulfhake - Frontiers in genetics, 2021 - frontiersin.org
We here review the loss of muscle function and mass (sarcopenia) in the framework of
human healthspan and lifespan, and mechanisms involved in aging. The rapidly changing …

A neuromuscular perspective of sarcopenia pathogenesis: Deciphering the signaling pathways involved

A Moreira-Pais, R Ferreira, PA Oliveira, JA Duarte - Geroscience, 2022 - Springer
The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

The TOR pathway at the neuromuscular junction: more than a metabolic player?

P Castets, DJ Ham, MA Rüegg - Frontiers in molecular neuroscience, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and
skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like …

Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

R Rudolf, IC Kettelhut, LCC Navegantes - Journal of Muscle Research …, 2024 - Springer
Neuromuscular junctions are the synapses between motor neurons and skeletal muscle
fibers, which mediate voluntary muscle movement. Since neuromuscular junctions are also …

Denervation-related neuromuscular junction changes: from degeneration to regeneration

X Huang, J Jiang, J Xu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted
muscle, which undergo degeneration during denervation periods. Denervation-related …

Oxytocin induces anti-catabolic and anabolic effects on protein metabolism in the female rat oxidative skeletal muscle

DM Costa, J da Cruz-Filho, ABS Vasconcelos… - Life Sciences, 2021 - Elsevier
Aims Although it is well established that skeletal muscle contains oxytocin (OT) receptors
and OT-knockout mice show premature development of sarcopenia, the role of OT in …

CHRNA1 induces sarcopenia through neuromuscular synaptic elimination

Z Liao, M Xiao, J Chen, Y Yang, Q Lyu, J Zhou… - Experimental …, 2022 - Elsevier
Sarcopenia seriously affects the quality of life of the elderly, but its molecular mechanism is
still unclear. Degeneration in muscle innervation is related to age-related movement …

Regulatory function of sympathetic innervation on the endo/lysosomal trafficking of acetylcholine receptor

T Straka, C Schröder, A Roos, L Kollipara… - Frontiers in …, 2021 - frontiersin.org
Recent studies have demonstrated that neuromuscular junctions are co-innervated by
sympathetic neurons. This co-innervation has been shown to be crucial for neuromuscular …

AMPK/MTOR/TP53 Signaling Pathway Regulation by Calcitonin Gene-Related Peptide Reduces Oxygen-Induced Lung Damage in Neonatal Rats through Autophagy …

S Wang, Z Zou, Z Tang, J Deng - Inflammation, 2024 - Springer
Our previous studies indicated that calcitonin gene-related peptide (CGRP) alleviates
hyperoxia-induced lung injury and suggested the possible involvement of autophagy in this …