The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Prion proteins have the unusual capacity to fold into two functionally distinct conformations,
one of which is self-perpetuating. When yeast prion proteins switch state, they produce …

AAUAAA is the most highly conserved motif in eukaryotic mRNA polyadenylation sites and,
in mammals, is specifically recognized by the multisubunit CPSF (cleavage and …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3′
processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the …

The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …