The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

K Dua, R Wadhwa, G Singhvi, V Rapalli… - Drug development …, 2019 - Wiley Online Library
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Macrophage activation and polarization as an adaptive component of innate immunity

M Locati, A Mantovani, A Sica - Advances in immunology, 2013 - Elsevier
Innate immunity has an adaptive component, which has been referred to as
“memory,”“trained,”“imprinted” or “adaptive.” Plasticity is a hallmark of cells of the monocyte …

[HTML][HTML] Disordered microbial communities in asthmatic airways

M Hilty, C Burke, H Pedro, P Cardenas, A Bush… - PloS one, 2010 - journals.plos.org
Background A rich microbial environment in infancy protects against asthma, and infections
precipitate asthma exacerbations. We compared the airway microbiota at three levels in …

[HTML][HTML] Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae

AM Smith, FR Adler, RM Ribeiro, RN Gutenkunst… - PLoS …, 2013 - journals.plos.org
Secondary bacterial infections are a leading cause of illness and death during epidemic and
pandemic influenza. Experimental studies suggest a lethal synergism between influenza …

[HTML][HTML] Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages

J Wang, F Li, R Sun, X Gao, H Wei, LJ Li… - Nature communications, 2013 - nature.com
While the presence of airway bacteria is known to be associated with improved immunity
against influenza virus, the mechanism by which endogenous microbiota influence antiviral …

[HTML][HTML] Immune defenses of the mammary gland epithelium of dairy ruminants

P Rainard, FB Gilbert, P Germon - Frontiers in immunology, 2022 - frontiersin.org
The epithelium of the mammary gland (MG) fulfills three major functions: nutrition of progeny,
transfer of immunity from mother to newborn, and its own defense against infection. The …

Pediatric bronchiectasis: no longer an orphan disease

V Goyal, K Grimwood, J Marchant… - Pediatric …, 2016 - Wiley Online Library
Bronchiectasis is described classically as a chronic pulmonary disorder characterized by a
persistent productive cough and irreversible dilatation of one or more bronchi. However, in …

Respiratory epithelial cells in innate immunity to influenza virus infection

CJ Sanders, PC Doherty, PG Thomas - Cell and tissue research, 2011 - Springer
Infection by influenza virus leads to respiratory failure characterized by acute lung injury
associated with alveolar edema, necrotizing bronchiolitis, and excessive bleeding. Severe …

[图书][B] Anthropology of infectious disease

M Singer - 2016 - taylorfrancis.com
This book synthesizes the flourishing field of anthropology of infectious disease in a critical,
biocultural framework. Leading medical anthropologist Merrill Singer holistically unites the …

The non-specific effects of vaccines

F Shann - Archives of disease in childhood, 2010 - adc.bmj.com
The simplistic conventional model of immunisation is no longer valid: we cannot assume that
a vaccine acts independently from other vaccines or that it influences only infections caused …