Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid
oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic …

Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …

In addition to controlling blood pressure, cardiac natriuretic peptides (NPs) can stimulate
lipolysis in adipocytes and promote the “browning” of white adipose tissue. NPs may also …

Atrial natriuretic peptide (ANP) has been considered to exert an essential role as a cardiac
secretory hormone in the regulation of hemodynamic homeostasis. As the research …

Intermittent fasting (IF) is gaining popularity for its effectiveness in improving overall health,
including its effectiveness in achieving weight loss and euglycemia. The molecular …

Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of
patients with heart failure. Clinically, HFpEF prevalence shows age and gender biases …

Heart failure with preserved ejection fraction (HFpEF) is highly prevalent, accounting for
50% of all heart failure patients, and is associated with significant mortality. Sodium–glucose …

Cardiac fibrosis is insidious, accelerating cardiovascular diseases, heart failure, and death.
With a notable lack of effective therapies, advances in both understanding and targeted …

G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated
early on in response to several forms of cardiovascular stress and are a hallmark of heart …