Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …

The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human
malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In …

Background Dose-dependent processes are common within biological systems and include
phenotypic changes following exposures to both endogenous and xenobiotic molecules …

Among the multiple metabolic signals involved in the establishment of the hepatic zonation,
oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic …

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not
always liver, diseases impair proper metabolic zonation. Various underlying pathways, such …

Two-photon imaging has attracted increasing attention owing to its deep tissue imaging
capabilities. Therefore, many fluorophores have been developed to satisfy its requirements …

In insulin-resistant states (obesity, pre-diabetes, and type 2 diabetes), hepatic production of
glucose and lipid synthesis are heightened in concert, implying that insulin deficiency and …

A pronounced heterogeneity between hepatocytes in subcellular structure and enzyme
activities was discovered more than 50 years ago and initiated the idea of metabolic …