Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Bone healing is associated with many orthopedic conditions, including fractures and
osteonecrosis, arthritis, metabolic bone disease, tumors and periprosthetic particle …

Osteoarthritis (OA) is a multifaceted musculoskeletal disorder, with a high prevalence
worldwide. Articular cartilage and synovial membrane are among the main biological targets …

Inflammation is a major risk factor for osteoporosis, and reducing inflammatory levels is
important for the prevention of osteoporosis. Although nuclear receptor 77 (Nur77) protects …

Joint destruction is the major clinic burden in patients with rheumatoid arthritis (RA). It is
unclear, though, how this autoimmune disease progresses to the point of deterioration of the …

Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance
between bone resorption and bone formation. The regulation of physiological bone …

New nanoparticles and biomaterials are increasingly being used in biomedical research for
drug delivery, diagnostic applications, or vaccines, and they are also present in numerous …

Inflammation leads to systemic osteoporosis or local bone destruction, however, the
underlying molecular mechanisms are still poorly understood. In this study, we report that …

This review focuses on one of the 16 proteins composing the V-ATPase complex
responsible for resorbing bone: the a 3 subunit. The rationale for focusing on this …

Osteoporosis is a skeletal disorder characterized by impaired bone strength and increased
risk of fragility fracture and is among the most relevant comorbidities of rheumatic diseases …