Endoplasmic reticulum stress and lipids in health and diseases
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
Effect of quercetin on nonshivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice
Activating nonshivering thermogenesis in brown adipose tissue (BAT) is a promising
strategy to prevent obesity. This study investigated whether quercetin supplementation …
strategy to prevent obesity. This study investigated whether quercetin supplementation …
Structure, function, and lipid sensing activity in the thioesterase superfamily
M Little, EA Ortlund - Biochemical Society Transactions, 2024 - portlandpress.com
Lipid synthesis and transport are essential for energy, production of cell membrane, and cell
signaling. Acyl-CoA thioesterases (ACOTs) function to regulate intracellular levels of fatty …
signaling. Acyl-CoA thioesterases (ACOTs) function to regulate intracellular levels of fatty …
Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice
R Janoschek, M Handwerk… - Nutrition & …, 2023 - Springer
The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since
standardization is missing and assuming that individual compositions provoke individual …
standardization is missing and assuming that individual compositions provoke individual …
[HTML][HTML] Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity
DS Sinden, CD Holman, CJ Bare, X Sun… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Abstract Fibroblast growth factor (FGF) 13, a nonsecreted, X-linked, FGF homologous factor,
is differentially expressed in adipocytes in response to diet, yet Fgf13's role in metabolism …
is differentially expressed in adipocytes in response to diet, yet Fgf13's role in metabolism …
[HTML][HTML] Sex-and age-associated factors drive the pathophysiology of MASLD
AK Yadav, JJ MacNeill, A Krylov, N Ashrafi… - Hepatology …, 2024 - journals.lww.com
Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is strongly
associated with obesity. Sex and age affect MASLD prevalence and pathophysiology. The …
associated with obesity. Sex and age affect MASLD prevalence and pathophysiology. The …
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver …
CS Krumm, RS Landzberg, L Ramos-Espiritu… - Molecular …, 2023 - Elsevier
Abstract Objective Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA
thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C …
thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C …
Suppression of Fatty Acid Oxidation by Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance
N Imai, HT Nicholls, M Alves-Bezerra, Y Li, AA Ivanova… - bioRxiv, 2021 - biorxiv.org
ABSTRACT Thioesterase superfamily member 2 (Them2) is highly expressed in oxidative
tissues where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA …
tissues where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA …
Inhibitors of them1
DE Cohen, C Krumm, J Ginn - US Patent App. 18/116,625, 2023 - Google Patents
US20230286955A1 - Inhibitors of them1 - Google Patents US20230286955A1 - Inhibitors of
them1 - Google Patents Inhibitors of them1 Info Publication number US20230286955A1 …
them1 - Google Patents Inhibitors of them1 Info Publication number US20230286955A1 …
[图书][B] Untersuchung des Gallensäurestoffwechsels der Slc10a5 Knockout-Maus
M Holtemeyer - 2020 - jlupub.ub.uni-giessen.de
Seit mehr als einem Jahrzehnt ist SLC10A5 nun Mitglied der Familie der
natriumabhängigen Gallensäuretransporter. Diese Verwandtschaft ließ, basierend auf den …
natriumabhängigen Gallensäuretransporter. Diese Verwandtschaft ließ, basierend auf den …