Intestinal hyperpermeability is a complex metabolic process mediated by different pathways
in close relation to the gut microbiota. Previous studies suggested that the gut microbiota is …

Background Current noninvasive methods for assessing intestinal inflammation in
inflammatory bowel disease (IBD) remain unsatisfactory. Along with C-reactive protein and …

Zwitterionic capsular polysaccharides (ZPSs) are bacterial products that modulate T cells,
including inducing anti-inflammatory IL-10-secreting T regulatory cells (Tregs). However …

One would assume that the anti-inflammatory activity of α1-anti-trypsin (AAT) is the result of
inhibiting neutrophil enzymes. However, AAT exhibits tolerogenic activities that are difficult …

Gastrointestinal (GI) diseases comprise a large spectrum of clinical conditions ranging from
indigestion to inflammatory bowel diseases (IBDs) and carcinomas. Endoscopy is the usual …

Tandem mass spectrometry based shotgun proteomics of distal gut microbiomes is
exceedingly difficult due to the inherent complexity and taxonomic diversity of the samples …

Given the global burden of diarrheal diseases on healthcare it is surprising how little is
known about the drivers of disease severity. Colitis caused by infection and inflammatory …

Pro-inflammatory cytokine TNFα antagonizes regulatory T cell (Treg) suppressive function
with a measurable reduction of IL-10 protein secretion. Tregs are critical to suppress …

Neutrophils are short-lived cells that play a crucial role in inflammation. As in other tissues,
these polymorphonuclear phagocytes are involved in the intestinal inflammatory response …

Colitis-associated colon cancer (CAC) accompanies the massive infiltration of neutrophils
during tumorigenesis and progression of CAC. Depletion of neutrophils in circulation results …