Microbiome-based therapeutics
MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Treatment of inflammatory bowel disease: a comprehensive review
Z Cai, S Wang, J Li - Frontiers in medicine, 2021 - frontiersin.org
Inflammatory bowel disease (IBD), as a global disease, has attracted much research
interest. Constant research has led to a better understanding of the disease condition and …
interest. Constant research has led to a better understanding of the disease condition and …
Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Previous studies have suggested that the gut microbiome influences the response to
checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial …
checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial …
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …
difficile infection and is considered a promising treatment for other microbiome-related …
Newer biologic and small-molecule therapies for inflammatory bowel disease
DC Baumgart, C Le Berre - New England Journal of Medicine, 2021 - Mass Medical Soc
Newer Biologic and Small-Molecule Therapies for IBD There is still no cure for inflammatory
bowel disease. This review covers newer treatments that reflect our understanding of the …
bowel disease. This review covers newer treatments that reflect our understanding of the …
Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues
M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …
microbiota. The past two decades have witnessed increasing interest in studying the gut …
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …
the pathogenesis of disease, has been identified over the past two decades. One of the …
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …
Pathophysiology of inflammatory bowel diseases
JT Chang - New England Journal of Medicine, 2020 - Mass Medical Soc
Pathophysiology of Inflammatory Bowel Diseases Research on IBDs has identified disrupted
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …