The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

Polymorphonuclear neutrophils (PMNs) are innate immune cells, which represent 50% to
70% of the total circulating leukocytes. How PMNs adapt to various microenvironments …

Neutrophils can function and survive in injured and infected tissues, where oxygen and
metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13 …

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …

Oxygen (O 2) availability is a key factor regulating microbiota composition and the
homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived …

Neutrophil recruitment is not only vital for host defense, but also relevant in pathological
inflammatory reactions, such as sepsis. Model systems have been established to examine …

Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs
of infectious diseases. Immunity limits the severity of infectious diseases through resistance …

Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host
against invading pathogens. Neutrophils may kill pathogens intracellularly, following …

Osteomyelitis, a significant infection of bone tissue, gives rise to two main groups of
infection: acute and chronic. These groups are further categorized in terms of the duration of …

Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory
sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a …