ER as master regulator of membrane trafficking and organelle function
EM Wenzel, LA Elfmark, H Stenmark… - Journal of cell biology, 2022 - rupress.org
The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …
[HTML][HTML] Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
SM Migliano, EM Wenzel, H Stenmark - Current opinion in cell biology, 2022 - Elsevier
The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …
[HTML][HTML] NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick type C
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
[HTML][HTML] An ESCRT-III polymerization sequence drives membrane deformation and fission
The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane
fission from within membrane necks, a process that is essential for many cellular functions …
fission from within membrane necks, a process that is essential for many cellular functions …
[HTML][HTML] Vps60 initiates alternative ESCRT-III filaments
AK Pfitzner, H Zivkovic, C Bernat-Silvestre… - Journal of Cell …, 2023 - rupress.org
Endosomal sorting complex required for transport-III (ESCRT-III) participates in essential
cellular functions, from cell division to endosome maturation. The remarkable increase of its …
cellular functions, from cell division to endosome maturation. The remarkable increase of its …
[HTML][HTML] Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation
A Bertin, N De Franceschi, E de La Mora… - Nature …, 2020 - nature.com
Endosomal sorting complexes for transport-III (ESCRT-III) assemble in vivo onto membranes
with negative Gaussian curvature. How membrane shape influences ESCRT-III …
with negative Gaussian curvature. How membrane shape influences ESCRT-III …
[HTML][HTML] Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily
Membrane remodeling and repair are essential for all cells. Proteins that perform these
functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in …
functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in …
[HTML][HTML] Principles of membrane remodeling by dynamic ESCRT-III polymers
Endosomal protein complex required for transport-III (ESCRT-III) polymers are involved in
many crucial cellular functions, from cell division to endosome–lysosome dynamics. As a …
many crucial cellular functions, from cell division to endosome–lysosome dynamics. As a …
Challenges and strategies: scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy
W Pan, H Chen, A Wang, F Wang, X Zhang - Life sciences, 2023 - Elsevier
Exosomes are small membrane vesicles secreted by most cell types, and widely exist in cell
supernatants and various body fluids. They can transmit numerous bioactive elements, such …
supernatants and various body fluids. They can transmit numerous bioactive elements, such …
[HTML][HTML] The ESCRT machinery: remodeling, repairing, and sealing membranes
Y Olmos - Membranes, 2022 - mdpi.com
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that
is used by the cell to perform reverse membrane scission in essential processes like protein …
is used by the cell to perform reverse membrane scission in essential processes like protein …