Astrocyte activation in neurovascular damage and repair following ischaemic stroke

A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

Recent breakthroughs and future directions in drugging aquaporins

MM Salman, P Kitchen, AJ Yool, RM Bill - Trends in pharmacological …, 2022 - cell.com
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …

Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Adaptable and multifunctional ion-conducting aquaporins

SD Tyerman, SA McGaughey, J Qiu… - Annual Review of …, 2021 - annualreviews.org
Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence
factors, and metabolon components. We consider plant aquaporins that transport ions …

Aquaporins in cancer biology

CS Moon, D Moon, SK Kang - Frontiers in oncology, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were
initially characterized as a novel protein family that plays a vital role in transcellular and …

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

V Montiel, R Bella, LYM Michel, H Esfahani… - Science translational …, 2020 - science.org
Pathological remodeling of the myocardium has long been known to involve oxidant
signaling, but strategies using systemic antioxidants have generally failed to prevent it. We …

Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …

Role of aquaporin 1 signalling in cancer development and progression

Y Tomita, H Dorward, AJ Yool, E Smith… - International journal of …, 2017 - mdpi.com
Cancer is a major health burden worldwide. Despite the advances in our understanding of
its pathogenesis and continued improvement in cancer management and outcomes, there …