Astrocyte activation in neurovascular damage and repair following ischaemic stroke
A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …
Recent breakthroughs and future directions in drugging aquaporins
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …
membranes. They are implicated in diverse pathologies including brain edema following …
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Adaptable and multifunctional ion-conducting aquaporins
Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence
factors, and metabolon components. We consider plant aquaporins that transport ions …
factors, and metabolon components. We consider plant aquaporins that transport ions …
Aquaporins in cancer biology
CS Moon, D Moon, SK Kang - Frontiers in oncology, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were
initially characterized as a novel protein family that plays a vital role in transcellular and …
initially characterized as a novel protein family that plays a vital role in transcellular and …
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide
V Montiel, R Bella, LYM Michel, H Esfahani… - Science translational …, 2020 - science.org
Pathological remodeling of the myocardium has long been known to involve oxidant
signaling, but strategies using systemic antioxidants have generally failed to prevent it. We …
signaling, but strategies using systemic antioxidants have generally failed to prevent it. We …
Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …
bidirectional transport of water across biological membranes in response to osmotic …
Mechanisms of aquaporin-facilitated cancer invasion and metastasis
ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …
expected to increase 70% in the next two decades. The fact that current mainline treatments …
Role of aquaporin 1 signalling in cancer development and progression
Cancer is a major health burden worldwide. Despite the advances in our understanding of
its pathogenesis and continued improvement in cancer management and outcomes, there …
its pathogenesis and continued improvement in cancer management and outcomes, there …