Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

[HTML][HTML] Current and novel therapeutic molecules and targets in Alzheimer's disease

A Kumar, CM Nisha, C Silakari, I Sharma… - Journal of the Formosan …, 2016 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells
causes memory loss and cognitive decline, ie, dementia. The disease starts with mild …

Acetylcholinesterase inhibitors: pharmacology and toxicology

MB Colovic, DZ Krstic… - Current …, 2013 - ingentaconnect.com
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …

Translation of pre-clinical studies into successful clinical trials for Alzheimer's disease: what are the roadblocks and how can they be overcome?

A Banik, RE Brown, J Bamburg… - Journal of …, 2015 - content.iospress.com
Preclinical studies are essential for translation to disease treatments and effective use in
clinical practice. An undue emphasis on single approaches to Alzheimer's disease (AD) …

Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives

H Nour, A Abdou, S Belaidi, JE Jamal… - Journal of the …, 2022 - Wiley Online Library
Cholinesterase enzymes are promising drug targets for the symptomatic treatment of
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …

Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius

TK Nguyen, KH Im, J Choi, PG Shin, TS Lee - Mycobiology, 2016 - Taylor & Francis
Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this
study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol …

Progress in target drug molecules for Alzheimer's disease

J Xie, R Liang, Y Wang, J Huang… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …

A review of brain atrophy subtypes definition and analysis for Alzheimer's disease heterogeneity studies

B Zhang, L Lin, S Wu - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Alzheimer's disease (AD) is a heterogeneous disease with different subtypes. Studying AD
subtypes from brain structure, neuropathology, and cognition are of great importance for AD …

Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening

N Atatreh, S Al Rawashdah, SS Al Neyadi… - Journal of Enzyme …, 2019 - Taylor & Francis
Butyrylcholinesterase (BChE) plays an important role in the progression of the Alzheimer's
disease. In this study, we used a structure-based virtual screening (VS) approach to discover …

Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design

SA Sehgal, MA Hammad, RA Tahir… - Current …, 2018 - ingentaconnect.com
Background: As the number of elderly persons increases, neurodegenerative diseases are
becoming ubiquitous. There is currently a great need for knowledge concerning …