Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
[HTML][HTML] Current and novel therapeutic molecules and targets in Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells
causes memory loss and cognitive decline, ie, dementia. The disease starts with mild …
causes memory loss and cognitive decline, ie, dementia. The disease starts with mild …
Acetylcholinesterase inhibitors: pharmacology and toxicology
MB Colovic, DZ Krstic… - Current …, 2013 - ingentaconnect.com
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
Translation of pre-clinical studies into successful clinical trials for Alzheimer's disease: what are the roadblocks and how can they be overcome?
Preclinical studies are essential for translation to disease treatments and effective use in
clinical practice. An undue emphasis on single approaches to Alzheimer's disease (AD) …
clinical practice. An undue emphasis on single approaches to Alzheimer's disease (AD) …
Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives
Cholinesterase enzymes are promising drug targets for the symptomatic treatment of
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading …
Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius
Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this
study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol …
study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol …
Progress in target drug molecules for Alzheimer's disease
J Xie, R Liang, Y Wang, J Huang… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
A review of brain atrophy subtypes definition and analysis for Alzheimer's disease heterogeneity studies
B Zhang, L Lin, S Wu - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Alzheimer's disease (AD) is a heterogeneous disease with different subtypes. Studying AD
subtypes from brain structure, neuropathology, and cognition are of great importance for AD …
subtypes from brain structure, neuropathology, and cognition are of great importance for AD …
Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
N Atatreh, S Al Rawashdah, SS Al Neyadi… - Journal of Enzyme …, 2019 - Taylor & Francis
Butyrylcholinesterase (BChE) plays an important role in the progression of the Alzheimer's
disease. In this study, we used a structure-based virtual screening (VS) approach to discover …
disease. In this study, we used a structure-based virtual screening (VS) approach to discover …
Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design
Background: As the number of elderly persons increases, neurodegenerative diseases are
becoming ubiquitous. There is currently a great need for knowledge concerning …
becoming ubiquitous. There is currently a great need for knowledge concerning …