The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Simple Summary The conceptualization of a “hot” tumor microenvironment has been
characterized by mainly T cell infiltration, whereas,“cold” or “immune-deserted” tumors were …

Microgravity accelerates the aging of various physiological systems, and it is well
acknowledged that aged individuals and astronauts both have increased susceptibility to …

Cells create their own steering cues, or modify cues from their outside, for a number of
reasons. These include generating optimal, legible directional information; probing their …

Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active
plasmin is formed from plasminogen, which is found in high concentrations in the blood and …

Intravital microscopy and other direct-imaging techniques have allowed for a
characterisation of leukocyte migration that has revolutionised the field of immunology …

Immune cells in the tumor microenvironment (TME) are known to affect tumor growth,
vascularization, and extracellular matrix (ECM) deposition. Marked interest in system-scale …

The tumor microenvironment (TME) represents the complex outcome of numerous tumor,
stromal, and immune interactions, and whose composition can significantly affect treatment …

The processes of aging and space travel both have significant adverse effects on the
immune system, resulting in increased susceptibility to infections. Using simulated …