Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer
therapeutics and their ligands have been developed as molecular probes in oncology …

Two problems that have hampered a receptor research are (i) a lack of high-affinity agents
and (ii) the recent identification of multiple populations of a receptors (ie, a\and< 72 sites) …

The invention relates to methods for the treatment of central nervous system disorders,
gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by …

Sigma-1 receptor (S1R) is involved in a large array of biological functions due to its ability to
interact with various proteins and ion channels. Crystal structures of human S1R revealed …

A lingering question in σ receptor ligand development is whether a nitrogen atom serves as
an important pharmacophoric element in binding affinity. To address this question, we have …

An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed
domino-isomerization–hydroamination reaction is presented. Starting from allylbenzene and …

The optical antipodes of iV-allyl-N-normetazocine (2; SKF 10047, NANM) were the original
compounds used for the classification of the a receptor as distinct from otherreceptors such …

Reference material was synthesised for 21 substances that are frequently present as
synthetic impurities, ie by-products, in illicitly produced amphetamine. Each of these …

Abstract [3 H](+)-Pentazocine binding has been characterized in the rat brain. It binds to a
single population of binding sites with affinity of about 7 nM and density of 280 fmol/mg …