Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

The process of cardiac morphogenesis in humans is incompletely understood. Its full
characterization requires a deep exploration of the organ-wide orchestration of gene …

Single-cell RNA sequencing is a powerful tool to study developmental biology but does not
preserve spatial information about tissue morphology and cellular interactions. Here, we …

Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not
only play a key role in maintaining vascular structure but also perform various functions …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

Coronary artery disease causes acute myocardial infarction and heart failure. Identifying
coronary vascular progenitors and their developmental program could inspire novel …

The heart is the first organ to be functional in the fetus. Heart formation is a complex
morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital …