Quantum biology: An update and perspective
Understanding the rules of life is one of the most important scientific endeavours and has
revolutionised both biology and biotechnology. Remarkable advances in observation …
revolutionised both biology and biotechnology. Remarkable advances in observation …
Mechanism of nitric oxide synthase regulation: electron transfer and interdomain interactions
C Feng - Coordination chemistry reviews, 2012 - Elsevier
Mammalian nitric oxide synthase (NOS), a flavo-hemoprotein, tightly regulates nitric oxide
(NO) synthesis and thereby its dual biological activities as a key signaling molecule for …
(NO) synthesis and thereby its dual biological activities as a key signaling molecule for …
Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
SB Jensen, S Thodberg, S Parween, ME Moses… - Nature …, 2021 - nature.com
Metabolic control is mediated by the dynamic assemblies and function of multiple redox
enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates …
enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates …
NADPH–cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family
NADPH–cytochrome P450 oxidoreductase (CYPOR) and nitric oxide synthase (NOS), two
members of the diflavin oxidoreductase family, are multi-domain enzymes containing distinct …
members of the diflavin oxidoreductase family, are multi-domain enzymes containing distinct …
Plasticity of specialized metabolism as mediated by dynamic metabolons
The formation of specialized metabolites enables plants to respond to biotic and abiotic
stresses, but requires the sequential action of multiple enzymes. To facilitate swift production …
stresses, but requires the sequential action of multiple enzymes. To facilitate swift production …
Local Electric Fields Drives the Proton-Coupled Electron Transfer within Cytochrome P450 Reductase
Cytochrome P450 enzymes play a pivotal role in biosynthetic and metabolic transformations.
Especially, cytochrome P450 reductase (CPR) acts as the key electron donor for the oxygen …
Especially, cytochrome P450 reductase (CPR) acts as the key electron donor for the oxygen …
Understanding and tuning the catalytic bias of hydrogenase
A Abou Hamdan, S Dementin, PP Liebgott… - Journal of the …, 2012 - ACS Publications
When enzymes are optimized for biotechnological purposes, the goal often is to increase
stability or catalytic efficiency. However, many enzymes reversibly convert their substrate …
stability or catalytic efficiency. However, many enzymes reversibly convert their substrate …
Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding
C Xia, D Hamdane, AL Shen, V Choi, CB Kasper… - Journal of Biological …, 2011 - ASBMB
The crystal structure of NADPH-cytochrome P450 reductase (CYPOR) implies that a large
domain movement is essential for electron transfer from NADPH via FAD and FMN to its …
domain movement is essential for electron transfer from NADPH via FAD and FMN to its …
Electron transfer partners of cytochrome P450
L Waskell, JJP Kim - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract NADPH-cytochrome P450 oxidoreductase (POR) is the obligatory flavoprotein
electron donor to microsomal cytochromes P450 (P450). POR is a diflavin protein containing …
electron donor to microsomal cytochromes P450 (P450). POR is a diflavin protein containing …
Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase
WC Huang, J Ellis, PCE Moody, EL Raven… - Structure, 2013 - cell.com
NADPH-cytochrome P450 reductase is a key component of the P450 mono-oxygenase drug-
metabolizing system. There is evidence for a conformational equilibrium involving large …
metabolizing system. There is evidence for a conformational equilibrium involving large …