Radical-based regioselective C–H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability
F O'Hara, DG Blackmond, PS Baran - Journal of the American …, 2013 - ACS Publications
Radical addition processes can be ideally suited for the direct functionalization of
heteroaromatic bases, yet these processes are only sparsely used due to the perception of …
heteroaromatic bases, yet these processes are only sparsely used due to the perception of …
[PDF][PDF] Aryl-and heteroaryl-thiosemicarbazone derivatives and their metal complexes: a pharmacological template
In this review, we discuss the current patents concerning aryl/heteroaryl thiosemicarbazone
derivatives as regards to their activities and properties, including coordination (chelation) …
derivatives as regards to their activities and properties, including coordination (chelation) …
Recent synthetic approaches towards small molecule reactivators of p53
The tumor suppressor protein p53 is often called “the genome guardian” and controls the
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …
Cancer cell resistance against the clinically investigated thiosemicarbazone COTI-2 is based on formation of intracellular copper complex glutathione adducts and …
JH Bormio Nunes, S Hager, M Mathuber… - Journal of medicinal …, 2020 - ACS Publications
COTI-2 is a novel anticancer thiosemicarbazone in phase I clinical trial. However, the effects
of metal complexation (a main characteristic of thiosemicarbazones) and acquired …
of metal complexation (a main characteristic of thiosemicarbazones) and acquired …
Aryl-and heteroaryl-thiosemicarbazone derivatives and their metal complexes: A pharmacological template
N SHN Moorthy, N MFSA Cerqueira… - Recent Patents on …, 2013 - ingentaconnect.com
In this review, we discuss the current patents concerning aryl/heteroaryl thiosemicarbazone
derivatives as regards to their activities and properties, including coordination (chelation) …
derivatives as regards to their activities and properties, including coordination (chelation) …