Network medicine framework for identifying drug-repurposing opportunities for COVID-19
D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
Deep learning of pharmacogenomics resources: moving towards precision oncology
The recent accumulation of cancer genomic data provides an opportunity to understand how
a tumor's genomic characteristics can affect its responses to drugs. This field, called …
a tumor's genomic characteristics can affect its responses to drugs. This field, called …
Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Cas9 is commonly introduced into cell lines to enable CRISPR–Cas9-mediated genome
editing. Here, we studied the genetic and transcriptional consequences of Cas9 expression …
editing. Here, we studied the genetic and transcriptional consequences of Cas9 expression …
Morphology and gene expression profiling provide complementary information for mapping cell state
Morphological and gene expression profiling can cost-effectively capture thousands of
features in thousands of samples across perturbations by disease, mutation, or drug …
features in thousands of samples across perturbations by disease, mutation, or drug …
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
Although genomic analyses predict many noncanonical open reading frames (ORFs) in the
human genome, it is unclear whether they encode biologically active proteins. Here we …
human genome, it is unclear whether they encode biologically active proteins. Here we …
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies
The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular
processes that fuel the malignant transformation of normal cells. The molecular aberrations …
processes that fuel the malignant transformation of normal cells. The molecular aberrations …
Pharmacogenomics and big genomic data: from lab to clinic and back again
The field of pharmacogenomics is an area of great potential for near-term human health
impacts from the big genomic data revolution. Pharmacogenomics research momentum is …
impacts from the big genomic data revolution. Pharmacogenomics research momentum is …
A cryogenic, coincident fluorescence, electron, and ion beam microscope
Cryogenic electron tomography (cryo-ET) combined with subtomogram averaging, allows in
situ visualization and structure determination of macromolecular complexes at …
situ visualization and structure determination of macromolecular complexes at …
Drug target inference by mining transcriptional data using a novel graph convolutional network framework
ABSTRACT A fundamental challenge that arises in biomedicine is the need to characterize
compounds in a relevant cellular context in order to reveal potential on-target or off-target …
compounds in a relevant cellular context in order to reveal potential on-target or off-target …
Side effect prediction based on drug-induced gene expression profiles and random forest with iterative feature selection
One in every ten drug candidates fail in clinical trials mainly due to efficacy and safety
related issues, despite in-depth preclinical testing. Even some of the approved drugs such …
related issues, despite in-depth preclinical testing. Even some of the approved drugs such …