There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion
molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc …

Over the past 25 years, antibodies have emerged as extraordinarily promising vectors for the
delivery of radionuclides to tumors for nuclear imaging. While radioimmunoconjugates often …

CD44 is a potentially rewarding target in cancer therapy, although its mechanisms of ligand
binding and internalization are still poorly understood. In this study, we have established …

Human monoclonal antibodies (mAbs) that target the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) spike protein have been isolated from convalescent …

Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that
express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic …

Thrombosis is a main complication of cancer. It can increase the mortality of cancer patients.
Therefore, the anticoagulant heparin (Hep) as an adjuvant therapy was introduced to the …

Serum biomarkers in the form of proteins (eg cluster of differentiation-44 (CD44)) have been
demonstrated to have high clinical sensitivity and specificity for disease diagnosis and …

An ideal protein therapeutic effect depends on the protein drug-carrying nanocarrier to
achieve high loading efficiency, excellent systemic stability, specific tumor targeting, rapid …

Background Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer
phototherapy that utilizes monoclonal antibody-IRDye700DX conjugates (mAb-IR700) and …

Human monoclonal antibodies from convalescent individuals that target the SARS-CoV-2
spike protein have been deployed as therapeutics against SARS-CoV-2. However, nearly all …