Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be
classified as an autoimmune disease remains unclear. In this study, we applied single-cell T …

According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

A large body of evidence produced during decades of research indicates that myocardial
injury activates innate immunity. On the one hand, innate immunity both aggravates …

Acute cardiomyocyte necrosis in the infarcted heart generates damage-associated
molecular patterns, activating complement and toll-like receptor/interleukin-1 signaling, and …

Experimental models of atherogenesis have provided a growing body of information about
molecular mechanisms of plaque growth; however, transition from coronary stability to …

Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …