A review of FLT3 kinase inhibitors in AML

C Negotei, A Colita, I Mitu, AR Lupu… - Journal of Clinical …, 2023 - mdpi.com
Acute myeloid leukemia (AML) is a highly aggressive illness distinguished by the
accumulation of abnormal hematopoietic precursors in both the bone marrow and peripheral …

[HTML][HTML] Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer

R Saesen, M Van Hemelrijck, J Bogaerts… - European Journal of …, 2023 - Elsevier
The emergence of the precision medicine paradigm in oncology has led to increasing
interest in the integration of real-world data (RWD) into cancer clinical research. As sources …

Glasdegib plus intensive or non-intensive chemotherapy for untreated acute myeloid leukemia: results from the randomized, phase 3 BRIGHT AML 1019 trial

MA Sekeres, P Montesinos, J Novak, J Wang… - Leukemia, 2023 - nature.com
This is the primary report of the randomized, placebo-controlled phase 3 BRIGHT AML 1019
clinical trial of glasdegib in combination with intensive chemotherapy (cytarabine and …

Broadening the horizon: potential applications of CAR-T cells beyond current indications

H Karsten, L Matrisch, S Cichutek, W Fiedler… - Frontiers in …, 2023 - frontiersin.org
Engineering immune cells to treat hematological malignancies has been a major focus of
research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several …

[图书][B] Geriatría

C D'hyver, LMG Robledo, CHZ Gil - 2024 - books.google.com
Geriatría, 5a ed. está dedicada para que los estudiantes de la licenciatura de medicina
tengan nociones básicas sobre la geriatría, a los médicos generales para que no se olviden …

Mapping AML heterogeneity-multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses

JF Severens, EO Karakaslar, BA van der Reijden… - Leukemia, 2024 - nature.com
Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic
abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense …

[HTML][HTML] Prognostic value of European LeukemiaNet 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia

S Park, TY Kim, BS Cho, D Kwag, JM Lee, M Kim… - …, 2024 - ncbi.nlm.nih.gov
This study aimed to validate the new European Leukemia Net (ELN) 2022 criteria for genetic
risk stratification in older adults with acute myeloid leukemia (AML) and to determine the …

Global, national, and regional burden of acute myeloid leukemia among 60–89 years-old individuals: insights from a study covering the period 1990 to 2019

P Chen, X Liu, Y Zhao, Y Hu, J Guo… - Frontiers in Public …, 2024 - frontiersin.org
Background Our study examined the global, national, and regional trends in the incidence,
mortality, and disability-adjusted life years (DALYs) associated with older people's acute …

MRD monitoring by multiparametric flow cytometry in AML: Is it time to incorporate immune parameters?

I Pessach, T Spyropoulos, E Lamprianidou… - Cancers, 2022 - mdpi.com
Simple Summary Measurable residual disease (MRD) is emerging as an important
prognostic and predictive biomarker in acute myeloid leukemia (AML). However, its use is …

Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?

ZLR Kaplan, N Van Leeuwen, D Van Klaveren… - BMJ …, 2024 - bmjoncology.bmj.com
Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission
induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may …