In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

H Arami, A Khandhar, D Liggitt… - Chemical Society …, 2015 - pubs.rsc.org
Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades,
either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs …

In vivo biodistribution and clearance of magnetic iron oxide nanoparticles for medical applications

J Nowak-Jary, B Machnicka - International Journal of …, 2023 - Taylor & Francis
Magnetic iron oxide nanoparticles (magnetite and maghemite) are intensively studied due to
their broad potential applications in medical and biological sciences. Their unique …

Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1

AC Illing, A Shawki, CL Cunningham… - Journal of Biological …, 2012 - ASBMB
Divalent metal-ion transporter-1 (DMT1) is a H+-coupled metal-ion transporter that plays
essential roles in iron homeostasis. DMT1 exhibits reactivity (based on evoked currents) with …

Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals

JM Moulis - Biometals, 2010 - Springer
The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …

Manganese and the brain

K Tuschl, PB Mills, PT Clayton - International review of neurobiology, 2013 - Elsevier
Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and
metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn …

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

S Jenkitkasemwong, CY Wang, B Mackenzie… - Biometals, 2012 - Springer
Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural
components of larger molecules that are indispensable for life. The three metal ions possess …

Mechanisms of lead and manganese neurotoxicity

AP Neal, TR Guilarte - Toxicology research, 2013 - academic.oup.com
Human exposure to neurotoxic metals is a global public health problem. Metals which cause
neurological toxicity, such as lead (Pb) and manganese (Mn), are of particular concern due …

Interactions of iron with manganese, zinc, chromium, and selenium as related to prophylaxis and treatment of iron deficiency

G Bjørklund, J Aaseth, AV Skalny, J Suliburska… - Journal of Trace …, 2017 - Elsevier
Iron (Fe) deficiency is considered as the most common nutritional deficiency. Iron deficiency
is usually associated with low Fe intake, blood loss, diseases, poor absorption …

Manganese neurotoxicity: a focus on the neonate

KM Erikson, K Thompson, J Aschner… - Pharmacology & …, 2007 - Elsevier
Manganese (Mn) is an essential trace metal found in all tissues, and it is required for normal
amino acid, lipid, protein, and carbohydrate metabolism. While Mn deficiency is extremely …

Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells

H Fujishiro, Y Yano, Y Takada, M Tanihara… - Metallomics, 2012 - academic.oup.com
Chronic exposure to cadmium causes preferential accumulation of cadmium in the kidney,
leading to nephrotoxicity. In the process of renal cadmium accumulation, the cadmium …