The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Ferroptosis‐related cancer therapy is limited by insufficient Fe2+/Fe3+ redox pair and
hydrogen peroxide (H2O2) for producing lethal hydroxyl radicals (· OH). Although …

RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable
crop protection. Compared with traditional double‐stranded (ds) RNA delivery systems …

The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

Gene delivery has attracted increasing interest as a highly promising therapeutic method to
treat various diseases, including both genetic and acquired disorders. Viral-vectors based …

Introduction: Intravenously injected nanoparticles, like any other foreign pathogen that
enters the body, encounter multiple lines of defense intended to neutralize and eliminate the …

Methods In this current study, cytogenomic impacts of 25 kD linear and branched PEI (LPEI
and BPEI, respectively) in A431 cells are reported to address possible mechanism for …

Gene therapy, ie, the expression in cells of genetic material with therapeutic activity, holds
great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral …

RNA interference (RNAi) described as post transcriptional gene silencing offers great
opportunities for developing RNA insecticide for sustainable pest management. In the past …