Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to
the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is …

Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as the
omentum, which are covered by a single layer of mesothelial cells. Mesothelial cells are …

Integrin-dependent cell adhesions come in different shapes and serve in different cell types
for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Cerebral cavernous malformations (CCMs) are vascular lesions that can occur sporadically
or as a consequence of inherited loss-of-function mutations, predominantly in the genes …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …

The ageing skeleton experiences a progressive decline in the rate of bone formation, which
can eventually result in osteoporosis—a common disease characterized by reduced bone …

Cell adhesion to the extracellular matrix or to surrounding cells plays a key role in cell
proliferation and differentiation and is critical for proper tissue homeostasis. An important …

Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins
trigger the recruitment of large protein assemblies and strengthen cell adhesion. Both …