Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has
become a significant public health problem globally. The management of this issue using …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high
morbidity and mortality in cystic fibrosis (CF) and immunocompromised patients, including …

Emerging resistance to all available antibiotics highlights the need to develop new
antibiotics with novel mechanisms of action. Most of the currently used antibiotics target …

Carbapenems are last-resort antibiotics for treating bacterial infections. The widespread
acquisition of metallo-β-lactamases, such as VIM-2, contributes to the emergence of …

Metallo-β-lactamases (MBLs) are among the most challenging bacterial enzymes to
overcome. Aztreonam (ATM) is the only β-lactam not hydrolyzed by MBLs but is often …

Background Antibiotic overuse leads to the emergence of antibiotic resistance that threatens
immunocompromised cancer patients. Infections caused by MDR Gram-negative pathogens …

Although the lungs were considered to be sterile until recently, the advent of molecular
biology techniques, such as polymerase chain reaction, 16 S rRNA sequencing and …

The cell wall is an indispensable element of bacterial cells and a long-known target of many
antibiotics. Penicillin, the first discovered beta-lactam antibiotic inhibiting the synthesis of cell …