Structural basis of protein kinase C isoform function
SF Steinberg - Physiological reviews, 2008 - journals.physiology.org
Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
C1 domains exposed: from diacylglycerol binding to protein–protein interactions
F Colón-González, MG Kazanietz - … et Biophysica Acta (BBA)-Molecular and …, 2006 - Elsevier
C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …
The regulated assembly of a PKCɛ complex controls the completion of cytokinesis
The cell cycle is exquisitely controlled by multiple sequential regulatory inputs to ensure
fidelity. Here we demonstrate that the final step in division, the physical separation of …
fidelity. Here we demonstrate that the final step in division, the physical separation of …
Akt phosphorylates Connexin43 on Ser373, a “mode-1” binding site for 14-3-3
DJ Park, CJ Wallick, KD Martyn, AF Lau… - Cell communication & …, 2007 - Taylor & Francis
Connexin43 (Cx43) is a membrane-spanning protein that forms channels that bridge the
gap between adjacent cells and this allows for the intercellular exchange of information …
gap between adjacent cells and this allows for the intercellular exchange of information …
[HTML][HTML] STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function
BE Flucher, M Campiglio - Biochimica et Biophysica Acta (BBA)-Molecular …, 2019 - Elsevier
Excitation-contraction coupling is the signaling process by which action potentials control
calcium release and consequently the force of muscle contraction. Until recently, three triad …
calcium release and consequently the force of muscle contraction. Until recently, three triad …
Tuning the signalling output of protein kinase C
Precise control of the amplitude of protein kinase C (PKC) signalling is essential for cellular
homoeostasis, and disruption of this control leads to pathophysiological states such as …
homoeostasis, and disruption of this control leads to pathophysiological states such as …
Protein kinase C as a stress sensor
ME Barnett, DK Madgwick, DJ Takemoto - Cellular signalling, 2007 - Elsevier
While there are many reviews which examine the group of proteins known as protein kinase
C (PKC), the focus of this article is to examine the cellular roles of two PKCs that are …
C (PKC), the focus of this article is to examine the cellular roles of two PKCs that are …
Hypoxic preconditioning induced neuroprotection against cerebral ischemic injuries and its cPKCγ-mediated molecular mechanism
N Zhang, Y Yin, S Han, J Jiang, W Yang, X Bu… - Neurochemistry …, 2011 - Elsevier
As of yet, pharmacological treatments of stroke are only met with mediocre results, which are
either ineffective or confounded by adverse effects, thus calling for a better understanding of …
either ineffective or confounded by adverse effects, thus calling for a better understanding of …
[HTML][HTML] An Update on Protein Kinases as Therapeutic Targets—Part II: Peptides as Allosteric Protein Kinase C Modulators Targeting Protein–Protein Interactions
Human protein kinases are highly-sought-after drug targets, historically harnessed for
treating cancer, cardiovascular disease, and an increasing number of autoimmune and …
treating cancer, cardiovascular disease, and an increasing number of autoimmune and …
[HTML][HTML] STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads
M Campiglio, BE Flucher - Scientific reports, 2017 - nature.com
The adaptor protein STAC3 is essential for skeletal muscle excitation-contraction (EC)
coupling and a mutation in the STAC3 gene has been linked to a severe muscle disease …
coupling and a mutation in the STAC3 gene has been linked to a severe muscle disease …