Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

The cell cycle is exquisitely controlled by multiple sequential regulatory inputs to ensure
fidelity. Here we demonstrate that the final step in division, the physical separation of …

Connexin43 (Cx43) is a membrane-spanning protein that forms channels that bridge the
gap between adjacent cells and this allows for the intercellular exchange of information …

Excitation-contraction coupling is the signaling process by which action potentials control
calcium release and consequently the force of muscle contraction. Until recently, three triad …

Precise control of the amplitude of protein kinase C (PKC) signalling is essential for cellular
homoeostasis, and disruption of this control leads to pathophysiological states such as …

While there are many reviews which examine the group of proteins known as protein kinase
C (PKC), the focus of this article is to examine the cellular roles of two PKCs that are …

As of yet, pharmacological treatments of stroke are only met with mediocre results, which are
either ineffective or confounded by adverse effects, thus calling for a better understanding of …

Human protein kinases are highly-sought-after drug targets, historically harnessed for
treating cancer, cardiovascular disease, and an increasing number of autoimmune and …

The adaptor protein STAC3 is essential for skeletal muscle excitation-contraction (EC)
coupling and a mutation in the STAC3 gene has been linked to a severe muscle disease …