Recent trends in praziquantel nanoformulations for helminthiasis treatment

AC Mengarda, B Iles, JP F. Longo… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Infections caused by parasitic flatworms impose a considerable worldwide
health burden. Recently, World Health Organization launched its roadmap for neglected …

Nanoparticles for antiparasitic drug delivery

Y Sun, D Chen, Y Pan, W Qu, H Hao, X Wang, Z Liu… - Drug Delivery, 2019 - Taylor & Francis
As an emerging novel drug carrier, nanoparticles provide a promising way for effective
treatment of parasitic diseases by overcoming the shortcomings of low bioavailability, poor …

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

D Sepúlveda‐Crespo, RM Reguera… - Medicinal research …, 2020 - Wiley Online Library
Helminthiasis is one of the gravest problems worldwide. There is a growing concern on less
available anthelmintics and the emergence of resistance creating a major threat to human …

[HTML][HTML] Potential application of nanotechnology in the treatment, diagnosis, and prevention of schistosomiasis

A Qadeer, H Ullah, M Sohail, SZ Safi… - … in bioengineering and …, 2022 - frontiersin.org
Schistosomiasis is one of the neglected tropical diseases that affect millions of people
worldwide. Globally, it affects the economically poor countries, usually with the scarcity of …

[HTML][HTML] A review of nanotechnology for targeted anti-schistosomal therapy

TA Adekiya, PPD Kondiah, YE Choonara… - … in bioengineering and …, 2020 - frontiersin.org
Schistosomiasis is one of the major parasitic diseases and second most prevalent among
the group of neglected diseases. The prevalence of schistosomiasis may be due to …

The idiosyncratic efficacy of spironolactone-loaded PLGA nanoparticles against murine intestinal schistosomiasis

WE Abd El Hady, GA El-Emam, NE Saleh… - International Journal …, 2023 - Taylor & Francis
Background Schistosomiasis is a chronic debilitating parasitic disease accompanied with
severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the …

Loading praziquantel within solid lipid nanoparticles improved its schistosomicidal efficacy against the juvenile stage

NMFH Mogahed, MM El-Temsahy… - Experimental …, 2023 - Elsevier
Schistosomiasis is a devastating endemic water born tropical disease caused by a parasitic
flat worm of the genus Schistosoma. It is usually associated with poverty, causing significant …

Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke

SA Sabry, AM Abd El Razek, M Nabil, SM Khedr… - Drug Delivery, 2023 - Taylor & Francis
The brain is a vital organ that is protected from the general circulation and is distinguished
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …

A single oral dose of celecoxib-loaded solid lipid nanoparticles for treatment of different developmental stages of experimental schistosomiasis mansoni

EI Ibrahim, IF Abou-El-Naga, MM El-Temsahy… - Acta Tropica, 2022 - Elsevier
Schistosomiasis, a neglected tropical parasitic disease, is associated with severe pathology,
mortality and economic loss. The treatment and control of schistosomiasis depends mainly …

[HTML][HTML] Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni

MM Eissa, MZ El-Azzouni, LK El-Khordagui… - Parasites & vectors, 2020 - Springer
Background The control of schistosomiasis has been centered to date on a single drug,
praziquantel, with shortcomings including treatment failure, reinfection, and emergence of …