Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …

Chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting neurotoxic effect of
chemotherapy, is the most common reason for early cessation of cancer treatment. This can …

Following peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and
remodel the extracellular matrix allowing axonal regrowth. Although much evidence has …

This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the context
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …

Background Myelinating Schwann cells (mSCs) form myelin in the peripheral nervous
system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has …

Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …

Reactive oxygen species (ROS) contribute to sensitization of pain pathways during
neuropathic pain, but little is known about the primary sources of ROS production and how …