Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Hydrogen sulfide (H 2 S) was once considered to have only toxic properties, until it was
discovered to be an endogenous signaling molecule. The effects of H 2 S are dose …

The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …

Apoptosis and necroptosis are two regulated cell death mechanisms; however, the
interaction between these cell death pathways in vivo is unclear. Here we used cerebral …

Functional loss of endothelial cells will lead to development and progression of
atherosclerosis in diabetic patients. However, dysfunction of endothelial cells in diabetes …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Rationale: Nicotinamide adenine dinucleotide+(NAD+)-boosting therapy has emerged as a
promising strategy to treat various health disorders, while the underlying molecular …

Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …