The implications of IDH mutations for cancer development and therapy

CJ Pirozzi, H Yan - Nature reviews Clinical oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

S Han, Y Liu, SJ Cai, M Qian, J Ding, M Larion… - British journal of …, 2020 - nature.com
Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets

J Bi, S Chowdhry, S Wu, W Zhang, K Masui… - Nature Reviews …, 2020 - nature.com
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

In situ sprayed starvation/chemodynamic therapeutic gel for post‐surgical treatment of IDH1 (R132H) glioma

C Li, Y Wan, Y Zhang, LH Fu, NT Blum… - Advanced …, 2022 - Wiley Online Library
Complete resection of isocitrate dehydrogenase 1 (IDH1)(R132H) glioma is unfeasible and
the classic post‐surgical chemo/radiotherapy suffers from high recurrence and low survival …

The roles of glucose metabolic reprogramming in chemo-and radio-resistance

J Lin, L Xia, J Liang, Y Han, H Wang, L Oyang… - Journal of Experimental …, 2019 - Springer
Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The
aberrant glucose metabolism is associated with dramatically increased bioenergetics …

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

S Tommasini-Ghelfi, K Murnan, FM Kouri… - Science …, 2019 - science.org
Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative
decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD (P) H, and CO2. IDHs …

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

IC Hvinden, T Cadoux-Hudson, CJ Schofield… - Cell Reports …, 2021 - cell.com
The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …

2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data

CH Suh, HS Kim, SC Jung, CG Choi, SJ Kim - Neuro-oncology, 2018 - academic.oup.com
Background Noninvasive and accurate modality to predict isocitrate dehydrogenase (IDH)
mutant glioma may have great potential in routine clinical practice. We aimed to investigate …

Accelerated MR spectroscopic imaging—a review of current and emerging techniques

W Bogner, R Otazo, A Henning - NMR in Biomedicine, 2021 - Wiley Online Library
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches

C Navarro, Á Ortega, R Santeliz, B Garrido, M Chacín… - Pharmaceutics, 2022 - mdpi.com
The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …