The implications of IDH mutations for cancer development and therapy
CJ Pirozzi, H Yan - Nature reviews Clinical oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …
technological advances, new insights into the molecular mechanisms underlying glioma …
In situ sprayed starvation/chemodynamic therapeutic gel for post‐surgical treatment of IDH1 (R132H) glioma
Complete resection of isocitrate dehydrogenase 1 (IDH1)(R132H) glioma is unfeasible and
the classic post‐surgical chemo/radiotherapy suffers from high recurrence and low survival …
the classic post‐surgical chemo/radiotherapy suffers from high recurrence and low survival …
The roles of glucose metabolic reprogramming in chemo-and radio-resistance
J Lin, L Xia, J Liang, Y Han, H Wang, L Oyang… - Journal of Experimental …, 2019 - Springer
Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The
aberrant glucose metabolism is associated with dramatically increased bioenergetics …
aberrant glucose metabolism is associated with dramatically increased bioenergetics …
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
S Tommasini-Ghelfi, K Murnan, FM Kouri… - Science …, 2019 - science.org
Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative
decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD (P) H, and CO2. IDHs …
decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD (P) H, and CO2. IDHs …
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
IC Hvinden, T Cadoux-Hudson, CJ Schofield… - Cell Reports …, 2021 - cell.com
The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data
CH Suh, HS Kim, SC Jung, CG Choi, SJ Kim - Neuro-oncology, 2018 - academic.oup.com
Background Noninvasive and accurate modality to predict isocitrate dehydrogenase (IDH)
mutant glioma may have great potential in routine clinical practice. We aimed to investigate …
mutant glioma may have great potential in routine clinical practice. We aimed to investigate …
Accelerated MR spectroscopic imaging—a review of current and emerging techniques
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches
The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …
reprogramming. Reprogramming is a process mediated by multiple factors, including …