[HTML][HTML] Phytocannabinoids: origins and biosynthesis

T Gülck, BL Møller - Trends in plant science, 2020 - cell.com
Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

[HTML][HTML] Strategies for engineering natural product biosynthesis in fungi

E Skellam - Trends in Biotechnology, 2019 - cell.com
Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …

Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum

Y Araki, T Awakawa, M Matsuzaki… - Proceedings of the …, 2019 - National Acad Sciences
Ascofuranone (AF) and ascochlorin (AC) are meroterpenoids produced by various
filamentous fungi, including Acremonium egyptiacum (synonym: Acremonium …

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

Y He, B Wang, W Chen, RJ Cox, J He, F Chen - Biotechnology Advances, 2018 - Elsevier
High throughput genome sequencing has revealed a multitude of potential secondary
metabolites biosynthetic pathways that remain cryptic. Pathway reconstruction coupled with …

[HTML][HTML] The biochemistry of phytocannabinoids and metabolic engineering of their production in heterologous systems

K Blatt-Janmaat, Y Qu - International Journal of Molecular Sciences, 2021 - mdpi.com
The medicinal properties of cannabis and the its legal status in several countries and
jurisdictions has spurred the massive growth of the cannabis economy around the globe …

Cannabichromene

F Pollastro, D Caprioglio, D Del Prete… - Natural Product …, 2018 - journals.sagepub.com
Cannabinochromene (CBC, 1a) is the archetypal member of a class of more than twenty
isoprenylated 5-hydroxy-7-alkyl (aralky) benzo [2 H] pyranes first reported from Cannabis …

Naturally Occurring Organohalogen Compounds—A Comprehensive Review

GW Gribble - Naturally Occurring Organohalogen Compounds, 2023 - Springer
The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

Chromene meroterpenoids from Rhododendron dauricum L. and their anti-inflammatory effects

N Zhang, Y Xu, D Sun, Y Li, H Li, L Chen - Phytochemistry, 2024 - Elsevier
Rhododendron dauricum L. is a perennial herb belonging to the genus Rhododendron,
commonly utilized in formulations for treating coughs and bronchitis, as well as in herbal …

An aromatic farnesyltransferase functions in biosynthesis of the anti-HIV meroterpenoid daurichromenic acid

H Saeki, R Hara, H Takahashi, M Iijima… - Plant …, 2018 - academic.oup.com
Rhododendron dauricum produces daurichromenic acid, an anti-HIV meroterpenoid, via
oxidative cyclization of the farnesyl group of grifolic acid. The prenyltransferase (PT) that …

[HTML][HTML] Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae

T Awakawa, I Abe - Journal of Fungi, 2021 - mdpi.com
The heterologous gene expression system with Aspergillus oryzae as the host is an effective
method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction …