The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
The tubulin code: molecular components, readout mechanisms, and functions
C Janke - Journal of Cell Biology, 2014 - rupress.org
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
C Janke, J Chloë Bulinski - Nature reviews Molecular cell biology, 2011 - nature.com
Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …
that may explain the diverse functions of microtubules within cells and organisms. However …
The tubulin code at a glance
Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …
[HTML][HTML] A family of protein-deglutamylating enzymes associated with neurodegeneration
K Rogowski, J Van Dijk, MM Magiera, C Bosc… - Cell, 2010 - cell.com
Polyglutamylation is a posttranslational modification that generates glutamate side chains
on tubulins and other proteins. Although this modification has been shown to be reversible …
on tubulins and other proteins. Although this modification has been shown to be reversible …
Tubulin modifications and their cellular functions
All microtubules are built from a basic α/β-tubulin building block, yet subpopulations of
microtubules can be differentially marked by a number of post-translational modifications …
microtubules can be differentially marked by a number of post-translational modifications …
Post-translational modifications of microtubules
D Wloga, J Gaertig - Journal of cell science, 2010 - journals.biologists.com
Microtubules–polymers of tubulin–perform essential functions, including regulation of cell
shape, intracellular transport and cell motility. How microtubules are adapted to perform …
shape, intracellular transport and cell motility. How microtubules are adapted to perform …
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming
We present a high-quality (> 100× depth) Illumina genome sequence of the leaf-cutting ant
Acromyrmex echinatior, a model species for symbiosis and reproductive conflict studies. We …
Acromyrmex echinatior, a model species for symbiosis and reproductive conflict studies. We …
Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport
MM Magiera, S Bodakuntla, J Žiak, S Lacomme… - The EMBO …, 2018 - embopress.org
Posttranslational modifications of tubulin are emerging regulators of microtubule functions.
We have shown earlier that upregulated polyglutamylation is linked to rapid degeneration of …
We have shown earlier that upregulated polyglutamylation is linked to rapid degeneration of …
The chemical complexity of cellular microtubules: tubulin post‐translational modification enzymes and their roles in tuning microtubule functions
CP Garnham, A Roll‐Mecak - Cytoskeleton, 2012 - Wiley Online Library
Cellular microtubules are marked by abundant and evolutionarily conserved post‐
translational modifications that have the potential to tune their functions. This review focuses …
translational modifications that have the potential to tune their functions. This review focuses …