The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

The tubulin code: molecular components, readout mechanisms, and functions

C Janke - Journal of Cell Biology, 2014 - rupress.org
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

C Janke, J Chloë Bulinski - Nature reviews Molecular cell biology, 2011 - nature.com
Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

The tubulin code at a glance

S Gadadhar, S Bodakuntla, K Natarajan… - Journal of cell …, 2017 - journals.biologists.com
Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …

[HTML][HTML] A family of protein-deglutamylating enzymes associated with neurodegeneration

K Rogowski, J Van Dijk, MM Magiera, C Bosc… - Cell, 2010 - cell.com
Polyglutamylation is a posttranslational modification that generates glutamate side chains
on tubulins and other proteins. Although this modification has been shown to be reversible …

Tubulin modifications and their cellular functions

JW Hammond, D Cai, KJ Verhey - Current opinion in cell biology, 2008 - Elsevier
All microtubules are built from a basic α/β-tubulin building block, yet subpopulations of
microtubules can be differentially marked by a number of post-translational modifications …

Post-translational modifications of microtubules

D Wloga, J Gaertig - Journal of cell science, 2010 - journals.biologists.com
Microtubules–polymers of tubulin–perform essential functions, including regulation of cell
shape, intracellular transport and cell motility. How microtubules are adapted to perform …

The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming

S Nygaard, G Zhang, M Schiøtt, C Li, Y Wurm… - Genome …, 2011 - genome.cshlp.org
We present a high-quality (> 100× depth) Illumina genome sequence of the leaf-cutting ant
Acromyrmex echinatior, a model species for symbiosis and reproductive conflict studies. We …

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

MM Magiera, S Bodakuntla, J Žiak, S Lacomme… - The EMBO …, 2018 - embopress.org
Posttranslational modifications of tubulin are emerging regulators of microtubule functions.
We have shown earlier that upregulated polyglutamylation is linked to rapid degeneration of …

The chemical complexity of cellular microtubules: tubulin post‐translational modification enzymes and their roles in tuning microtubule functions

CP Garnham, A Roll‐Mecak - Cytoskeleton, 2012 - Wiley Online Library
Cellular microtubules are marked by abundant and evolutionarily conserved post‐
translational modifications that have the potential to tune their functions. This review focuses …