Recent developments of liquid chromatography stationary phases for compound separation: from proteins to small organic compounds

H Rusli, RM Putri, A Alni - Molecules, 2022 - mdpi.com
Compound separation plays a key role in producing and analyzing chemical compounds.
Various methods are offered to obtain high-quality separation results. Liquid …

Recent advances in chiral analysis of proteins and peptides

M Morvan, I Mikšík - Separations, 2021 - mdpi.com
Like many biological compounds, proteins are found primarily in their homochiral form.
However, homochirality is not guaranteed throughout life. Determining their chiral …

Comprehensive online reversed-phase× chiral two-dimensional liquid chromatography-mass spectrometry with data-independent sequential window acquisition of all …

R Karongo, J Horak, M Lämmerhofer - Analytical Chemistry, 2022 - ACS Publications
This work presents an advanced analytical platform for untargeted enantioselective amino
acid analysis (eAAA) by comprehensive achiral× chiral 2D-LC hyphenated to ESI-QTOF …

Enantioselective multiple heart cutting online two-dimensional liquid chromatography-mass spectrometry of all proteinogenic amino acids with second dimension …

R Karongo, M Ge, C Geibel, J Horak… - Analytica Chimica Acta, 2021 - Elsevier
In this work, we present a unique, robust and fully automated analytical platform technology
for the enantioselective amino acid analysis using a multiple heart cutting RPLC-enantio …

Enantioselective metabolomics by liquid chromatography-mass spectrometry

C Calderón, M Lämmerhofer - Journal of Pharmaceutical and Biomedical …, 2022 - Elsevier
Metabolomics strives to capture the entirety of the metabolites in a biological system by
comprehensive analysis, often by liquid chromatography hyphenated to mass spectrometry …

Development and validation of a chiral UHPLC-MS method for the analysis of cysteine enantiomers in biological samples

L Pucciarini, V González-Ruiz, J Zangari… - … of pharmaceutical and …, 2020 - Elsevier
For years, d-amino acids were thought to have a minor function in biological processes
compared to that of l-enantiomers. Recently, many studies have shown that d-amino acids …

Derivatization procedures and their analytical performances for HPLC determination in bioanalysis

V David, SC Moldoveanu… - Biomedical …, 2021 - Wiley Online Library
Derivatization, or chemical structure modification, is often used in bioanalysis performed by
liquid chromatography technique in order to enhance detectability or to improve the …

[HTML][HTML] A chiral metal-organic framework {(HQA)(ZnCl2)(2.5 H2O)} n for the enantioseparation of chiral amino acids and drugs

X Zheng, Q Zhang, Q Ma, X Li, L Zhao, X Sun - Journal of pharmaceutical …, 2023 - Elsevier
Chiral metal-organic frameworks (CMOFs) with enantiomeric subunits have been employed
in chiral chemistry. In this study, a CMOF formed from 6-methoxyl-(8S, 9R)-cinchonan-9-ol-3 …

Metabolic profiling of urinary chiral amino-containing biomarkers for gastric cancer using a sensitive chiral chlorine-labeled probe by HPLC-MS/MS

R Huang, K Shen, Q He, Y Hu, C Sun… - Journal of Proteome …, 2021 - ACS Publications
Screening of characteristic biomarkers from chiral amino-containing metabolites in
biological samples is difficult and important for the noninvasive diagnosis of gastric cancer …

[HTML][HTML] Features, roles and chiral analyses of proteinogenic amino acids

NJ Ayon - AIMS Molecular Science, 2020 - aimspress.com
Amino acids (AAs) are important biomolecules responsible for plethora of functions in both
prokaryotic and eukaryotic systems. There are 22 naturally occurring amino acids, among …