[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

D Geers, MC Shamier, S Bogers, G den Hartog… - Science …, 2021 - science.org
The emergence of SARS-CoV-2 variants harboring mutations in the spike (S) protein has
raised concern about potential immune escape. Here, we studied humoral and cellular …

Three waves changes, new variant strains, and vaccination effect against COVID-19 pandemic

RM El-Shabasy, MA Nayel, MM Taher… - International Journal of …, 2022 - Elsevier
It has been more than one year since the first case of the coronaviruses was infected by
COVID-19 in China. The world witnessed three waves of the corona virus till now, and more …

SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

A Grifoni, J Sidney, R Vita, B Peters, S Crotty… - Cell host & …, 2021 - cell.com
Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines

G McLean, J Kamil, B Lee, P Moore, TF Schulz, A Muik… - MBio, 2022 - Am Soc Microbiol
The emergence of several new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in recent months has raised concerns around the potential impact on …

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19

V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …