[HTML][HTML] Fibrosis and hepatocarcinogenesis: role of gene-environment interactions in Liver Disease Progression

A Banerjee, P Farci - International Journal of Molecular Sciences, 2024 - mdpi.com
The liver is a complex organ that performs vital functions in the body. Despite its
extraordinary regenerative capacity compared to other organs, exposure to chemical …

[HTML][HTML] Is HLA-E with its receptors an immune checkpoint or an antigenic determinant in allo-HCT?

H Rohn, V Rebmann - Best Practice & Research Clinical Haematology, 2024 - Elsevier
Hematopoietic cell transplantation (HCT) represents a potentially curative therapeutic
approach for various hematologic and non-hematologic malignancies. Human leukocyte …

HLA-E* 01: 01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E* 01: 03 allele increases the resistance to anti-HCV …

E Hosseini, ES Kazerooni, A Azarkeivan, Z Sharifi… - Human Immunology, 2022 - Elsevier
Background HLA-E binding to NKG2A/CD94 induces inhibitory signals that modulate NK
cells cytotoxicity against infected targets. HCV-derived peptides stabilize HLA-E molecule …

HLA-E* 01: 01+ HLA-E* 01: 01 genotype confers less susceptibility to COVID-19, while HLA-E* 01: 03+ HLA-E* 01: 03 genotype is associated with more severe …

E Hosseini, A Minagar, M Ghasemzadeh… - Human Immunology, 2023 - Elsevier
Background HLA-E interaction with inhibitory receptor, NKG2A attenuates NK-mediated
cytotoxicity. NKG2A overexpression by SARS-CoV-2 exhausts NK cells function, whereas …

Establishment of rapid detection methods for rs76971248 related to leukemia

LY Sun, Z Li, SX Wang, H Chen, ZT Sun… - Disease …, 2022 - Wiley Online Library
Background. The HLA‐E gene is a member of the HLA‐I gene family. Its genetic
polymorphism is regarded as associated with numerous diseases. Establishing a rapid and …

[PDF][PDF] Characteristics of human leukocyte antigen-e expression in transgenic porcine liver.

J Wiater, J Karasiński, R Słomski, Z Smorąg… - 2021 - igbzpan.pl
380 in pig cells affects the HLA-E expression pattern in triple transgenic liver. Here, we used
confocal immunofluorescence and Western blotting to study the distribution and …